Reading Frame - Multiple Reading Frames

Multiple Reading Frames

The usage of multiple reading frames leads to the possibility of overlapping genes; there may be many of these in virus, prokaryote, and mitochondrial genomes. Some viruses, e.g. Hepatitis B virus and BYDV, use several overlapping genes in different reading frames.

In rare cases, a translating ribosome may shift from one frame to another, a translational frameshift. This is distinct from a frameshift mutation, as the nucleotide sequence (DNA or RNA) is not altered—only the frame in which it is read.

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