In molecular genetics, an open reading frame (ORF) is the part of a reading frame that contains no stop codons. The transcription termination pause site is located after the ORF, beyond the translation stop codon, because if transcription were to cease before the stop codon, an incomplete protein would be made during translation.
Normally, inserts which interrupt the reading frame of a subsequent region after the start codon cause frameshift mutation of the sequence and dislocate the sequences for stop codons.
Read more about Open Reading Frame: Significance, Example
Famous quotes containing the words open, reading and/or frame:
“If we keep an open mind, too much is likely to fall into it.”
—Natalie Clifford Barney (1876–1972)
“After reading Howitt’s account of the Australian gold-diggings one evening,... I asked myself why I might not be washing some gold daily, though it were only the finest particles,—why I might not sink a shaft down to the gold within me, and work that mine.... At any rate, I might pursue some path, however solitary and narrow and crooked, in which I could walk with love and reverence.”
—Henry David Thoreau (1817–1862)
“she drew back a while,
Then, yielding to the irresistible joy,
With frantic gesture and short breathless cry
Folded his frame in her dissolving arms.
Now blackness veiled his dizzy eyes, and night
Involved and swallowed up the vision; sleep,
Like a dark flood suspended in its course,
Rolled back its impulse on his vacant brain.”
—Percy Bysshe Shelley (1792–1822)