In molecular genetics, an open reading frame (ORF) is the part of a reading frame that contains no stop codons. The transcription termination pause site is located after the ORF, beyond the translation stop codon, because if transcription were to cease before the stop codon, an incomplete protein would be made during translation.
Normally, inserts which interrupt the reading frame of a subsequent region after the start codon cause frameshift mutation of the sequence and dislocate the sequences for stop codons.
Read more about Open Reading Frame: Significance, Example
Famous quotes containing the words open, reading and/or frame:
“Manuel showed her his open hand: “Look at this finger, how meager it seems, and this one even weaker, and this other one no stronger, and this one all by himself and on his own.”
Then he made a fist: “But now, is it strong enough, big enough, solid enough? It seems so doesn’t it?””
—Jacques Roumain (1907–1945)
“Even the poor student studies and is taught only political economy, while that economy of living which is synonymous with philosophy is not even sincerely professed in our colleges. The consequence is, that while he is reading Adam Smith, Ricardo, and Say, he runs his father in debt irretrievably.”
—Henry David Thoreau (1817–1862)
“It would be nice to travel if you knew where you were going and where you would live at the end or do we ever know, do we ever live where we live, we’re always in other places, lost, like sheep.”
—Janet Frame (b. 1924)