Reading Frame

In molecular biology, a reading frame is a way of dividing the sequence of nucleotides in a nucleic acid (DNA or RNA) molecule into a set of consecutive, non-overlapping triplets. Where these triplets equate to amino acids or stop signals during translation, they are called codons.

A single strand of a nucleic acid molecule has a phosphoryl end, (called the 5′-end) and a hydroxyl, or (3′-end). These then define the 5'→3' direction. There are three reading frames that can be read in this 5'→3' direction, each beginning from a different nucleotide in a triplet. In a double stranded nucleic acid, an additional three reading frames may be read from the other, complementary strand in the 5'→3' direction along this strand. As the two strands of a double stranded nucleic acid molecule are antiparallel, the 5'→3' direction on the second strand corresponds to the 3'→5' direction along the first strand.

In general, at most one reading frame in a given section of a nucleic acid is biologically relevant.

Read more about Reading Frame:  Transcription, Translation, Multiple Reading Frames, Open Reading Frame

Famous quotes containing the words reading and/or frame:

    The logical English train a scholar as they train an engineer. Oxford is Greek factory, as Wilton mills weave carpet, and Sheffield grinds steel. They know the use of a tutor, as they know the use of a horse; and they draw the greatest amount of benefit from both. The reading men are kept by hard walking, hard riding, and measured eating and drinking, at the top of their condition, and two days before the examination, do not work but lounge, ride, or run, to be fresh on the college doomsday.
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