Quantitative Models Of The Action Potential
In neurophysiology, several mathematical models of the action potential have been developed, which fall into two basic types. The first type seeks to model the experimental data quantitatively, i.e., to reproduce the measurements of current and voltage exactly. The renowned Hodgkin-Huxley model of the axon from the Loligo squid exemplifies such models. Although qualitatively correct, the H-H model does not describe every type of excitable membrane accurately, since it considers only two ions (sodium and potassium), each with only one type of voltage-sensitive channel. However, other ions such as calcium may be important and there is a great diversity of channels for all ions. As an example, the cardiac action potential illustrates how differently shaped action potentials can be generated on membranes with voltage-sensitive calcium channels and different types of sodium/potassium channels. The second type of mathematical model is a simplification of the first type; the goal is not to reproduce the experimental data, but to understand qualitatively the role of action potentials in neural circuits. For such a purpose, detailed physiological models may be unnecessarily complicated and may obscure the "forest for the trees". The Fitzhugh-Nagumo model is typical of this class, which is often studied for its entrainment behavior. Entrainment is commonly observed in nature, for example in the synchronized lighting of fireflies, which is coordinated by a burst of action potentials; entrainment can also be observed in individual neurons. Both types of models may be used to understand the behavior of small biological neural networks, such as the central pattern generators responsible for some automatic reflex actions. Such networks can generate a complex temporal pattern of action potentials that is used to coordinate muscular contractions, such as those involved in breathing or fast swimming to escape a predator.
Read more about Quantitative Models Of The Action Potential: Hodgkin-Huxley Model, Fitzhugh-Nagumo Model, Extracellular Potentials and Currents
Famous quotes containing the words models, action and/or potential:
“Friends broaden our horizons. They serve as new models with whom we can identify. They allow us to be ourselves—and accept us that way. They enhance our self-esteem because they think we’re okay, because we matter to them. And because they matter to us—for various reasons, at various levels of intensity—they enrich the quality of our emotional life.”
—Judith Viorst (20th century)
“In the life of the human spirit, words are action, much more so than many of us may realize who live in countries where freedom of expression is taken for granted. The leaders of totalitarian nations understand this very well. The proof is that words are precisely the action for which dissidents in those countries are being persecuted.”
—Jimmy Carter (James Earl Carter, Jr.)
“If the Russians have gone too far in subjecting the child and his peer group to conformity to a single set of values imposed by the adult society, perhaps we have reached the point of diminishing returns in allowing excessive autonomy and in failing to utilize the constructive potential of the peer group in developing social responsibility and consideration for others.”
—Urie Bronfenbrenner (b. 1917)