Example
If a portion of a genome has been sequenced (e.g. 5'-ATCTAAAATGGGTGCC-3'), ORFs can be located by examining each of the three possible reading frames on each strand. In this sequence two out of three possible reading frames are entirely open, meaning that they do not contain a stop codon:
- ...A TCT AAA ATG GGT GCC...
- ...AT CTA AAA TGG GTG CC...
- ...ATC TAA AAT GGG TGC C...
Possible stop codons in DNA are "TGA", "TAA" and "TAG". Thus, the last reading frame in this example contains a stop codon (TAA), unlike the first two.
Read more about this topic: Open Reading Frame
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