An elimination reaction is a type of organic reaction in which two substituents are removed from a molecule in either a one or two-step mechanism. The one-step mechanism is known as the E2 reaction, and the two-step mechanism is known as the E1 reaction. The numbers do not have to do with the number of steps in the mechanism, but rather the kinetics of the reaction, bimolecular and unimolecular respectively.
In most organic elimination reactions, at least one hydrogen is lost to form the double bond: the unsaturation of the molecule increases. It is also possible that a molecule undergoes reductive elimination, by which the valence of an atom in the molecule decreases by two. An important class of elimination reactions are those involving alkyl halides, with good leaving groups, reacting with a Lewis base to form an alkene. Elimination may be considered the reverse of an addition reaction. When the substrate is asymmetric, regioselectivity is determined by Zaitsev's rule.
Read more about Elimination Reaction: E2 Mechanism, E1 Mechanism, E2 and E1 Elimination Final Notes, Specific Elimination Reactions
Famous quotes containing the words elimination and/or reaction:
“The kind of Unitarian
Who having by elimination got
From many gods to Three, and Three to One,
Thinks why not taper off to none at all.”
—Robert Frost (1874–1963)
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—Hannah Arendt (1906–1975)