Deep brain stimulation (DBS) is a surgical treatment involving the implantation of a medical device called a brain pacemaker, which sends electrical impulses to specific parts of the brain. DBS in select brain regions has provided remarkable therapeutic benefits for otherwise treatment-resistant movement and affective disorders such as chronic pain, Parkinson's disease, tremor and dystonia. Despite the long history of DBS, its underlying principles and mechanisms are still not clear. DBS directly changes brain activity in a controlled manner, its effects are reversible (unlike those of lesioning techniques) and is one of only a few neurosurgical methods that allows blinded studies.
The Food and Drug Administration (FDA) approved DBS as a treatment for essential tremor in 1997, for Parkinson's disease in 2002, and dystonia in 2003. DBS is also routinely used to treat chronic pain and has been used to treat various affective disorders, including major depression. While DBS has proven helpful for some patients, there is potential for serious complications and side effects.
Read more about Deep Brain Stimulation: Components and Placement, Biochemistry, Potential Complications and Side Effects
Famous quotes containing the words deep, brain and/or stimulation:
“Errors of taste are very often the outward sign of a deep fault of sensibility.”
—Jonathan Miller (b. 1936)
“Public morning diversions were the last dissipating habit she obtained; but when that was accomplished, her time was squandered away, the power of reflection was lost, [and] her ideas were all centered in dress, drums, routs, operas, masquerades, and every kind of public diversion. Visionary schemes of pleasure were continually present to her imagination, and her brain was whirled about by such a dizziness that she might properly be said to labor under the distemper called the vertigo.”
—Sarah Fielding (1710–1768)
“The lore of our fathers is a fabric of sentences. In our hands it develops and changes, through more or less arbitrary and deliberate revisions and additions of our own, more or less directly occasioned by the continuing stimulation of our sense organs. It is a pale gray lore, black with fact and white with convention. But I have found no substantial reasons for concluding that there are any quite black threads in it, or any white ones.”
—Willard Van Orman Quine (b. 1908)