Biochemistry
It has been shown in thalamic slices from mice that DBS causes nearby astrocytes to release adenosine triphosphate (ATP), a precursor to adenosine (through a catabolic process). In turn, adenosine A1 receptor activation depresses excitatory transmission in the thalamus, thus causing an inhibitory effect that mimicks ablation or "lesioning".
Read more about this topic: Deep Brain Stimulation
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