Vesicle associated membrane proteins (VAMP) are a family of SNARE proteins with similar structure, and are mostly involved in vesicle fusion.
- VAMP1 and VAMP2 proteins known as synaptobrevins are expressed in brain and are constituents of the synaptic vesicles, where they participate in neuromediator release.
- VAMP3 (known as cellubrevin) is ubiquitously expressed and participates in regulated and constitutive exocytosis as a constituent of secretory granules and secretory vesicles.
- VAMP5 and VAMP7 (SYBL1) participate in constitutive exocytosis.
- VAMP5 is a constituent of secretory vesicles, myotubes and tubulovesicular structures.
- VAMP7 is found both in secretory granules and endosomes.
- VAMP8 (known as endobrevin) participates in endocytosis and is found in early endosomes. VAMP8 also participates the regulated exocytosis in pancreatic acinar cells.
- VAMP4 is involved in transport from the Golgi.
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