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The second cohomology group of a closed simply connected oriented topological 4-manifold is a unimodular lattice. Michael Freedman showed that this lattice almost determines the manifold: there is a unique such manifold for each even unimodular lattice, and exactly two for each odd unimodular lattice. In particular if we take the lattice to be 0, this implies the Poincaré conjecture for 4 dimensional topological manifolds. Donaldson's theorem states that if the manifold is smooth and the lattice is positive definite, then it must be a sum of copies of Z, so most of these manifolds have no smooth structure.
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