In organic chemistry, a total synthesis is, in principle, the complete chemical synthesis of complex organic molecules from simpler pieces, usually without the aid of biological processes. In practice, these simpler pieces are commercially available in bulk and semi-bulk quantities, and are often petrochemical precursors. Sometimes bulk natural products (e.g. sugars) are used as starting materials and it is assumed that these have or can be synthesised from their constituent elements. The target molecules can be natural products (biomolecules), medicinally important active ingredients, or organic compounds of theoretical interest in chemistry or biology. A new route for synthesis is developed in the course of the investigation, and the route may be the first one to be developed for the substance.
Read more about Total Synthesis: History, Formal Synthesis, Examples
Famous quotes containing the words total and/or synthesis:
“only total expression
expresses hiding: I’ll have to say everything
to take on the roundness and withdrawal of the deep dark:
less than total is a bucketful of radiant toys.”
—Archie Randolph Ammons (b. 1926)
“It is not easy to construct by mere scientific synthesis a foolproof system which will lead our children in a desired direction and avoid an undesirable one. Obviously, good can come only from a continuing interplay between that which we, as students, are gradually learning and that which we believe in, as people.”
—Erik H. Erikson (20th century)