In total synthesis, the Quinine total synthesis describes the efforts in synthesis of quinine over a 150 year period. The development of synthetic quinine is considered a milestone in organic chemistry although it has never been produced industrially as a substitute for natural occurring quinine. The subject has also been attended with some controversy: in 2001 Gilbert Stork published the first stereoselective quinine synthesis and he shed doubt (calling it a myth) on the earlier claim in 1944 by Bob Woodward and William Doering on account that they had obtained not quinine but a precursor molecule. In 2001, an editorial in Chemical & Engineering News supported Storks claim but according to a critical 30 page review in this matter published in 2007 in Angewandte Chemie the Woodward/Doering claim is valid.
Read more about Quinine Total Synthesis: Background, Quinine Total Synthesis Timeline, Stork Quinine Total Synthesis, Woodward / Doering Formal Quinine Total Synthesis
Famous quotes containing the words total and/or synthesis:
“I only know that a rook
Ordering its black feathers can so shine
As to seize me senses, haul
My eyelids up, and grant
A brief respite from fear
Of total neutrality.”
—Sylvia Plath (1932–1963)
“Our art is the finest, the noblest, the most suggestive, for it is the synthesis of all the arts. Sculpture, painting, literature, elocution, architecture, and music are its natural tools. But while it needs all of those artistic manifestations in order to be its whole self, it asks of its priest or priestess one indispensable virtue: “faith.””
—Sarah Bernhardt (1845–1923)