In total synthesis, the Quinine total synthesis describes the efforts in synthesis of quinine over a 150 year period. The development of synthetic quinine is considered a milestone in organic chemistry although it has never been produced industrially as a substitute for natural occurring quinine. The subject has also been attended with some controversy: in 2001 Gilbert Stork published the first stereoselective quinine synthesis and he shed doubt (calling it a myth) on the earlier claim in 1944 by Bob Woodward and William Doering on account that they had obtained not quinine but a precursor molecule. In 2001, an editorial in Chemical & Engineering News supported Storks claim but according to a critical 30 page review in this matter published in 2007 in Angewandte Chemie the Woodward/Doering claim is valid.
Read more about Quinine Total Synthesis: Background, Quinine Total Synthesis Timeline, Stork Quinine Total Synthesis, Woodward / Doering Formal Quinine Total Synthesis
Famous quotes containing the words total and/or synthesis:
“The total collapse of the public opinion polls shows that this country is in good health. A country that developed an airtight system of finding out in advance what was in people’s minds would be uninhabitable.”
—E.B. (Elwyn Brooks)
“In order to begin an analysis, there must already be a synthesis present in the mind.”
—Johan Huizinga (1872–1945)