Serum sickness in humans is a reaction to proteins in antiserum derived from a non-human animal source, occurring 4–10 days after exposure. It is a type of hypersensitivity, specifically immune complex hypersensitivity (type III). The term serum sickness–like reaction (SSLR) is occasionally used to refer to similar illnesses that arise from the introduction of certain non-protein substances. It was first characterized by Clemens von Pirquet and Béla Schick in 1906.
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“Tempered, gradual animation, the methodical restrain of sensations and energies, the equilibrium of sickness and health in each creaturethis is natures essence, its immutable law, this is what its based on and what it adheres to.”
—Ivan Sergeevich Turgenev (18181883)