Total Synthesis
A total synthesis is the complete chemical synthesis of complex organic molecules from simple, commercially available (petrochemical) or natural precursors. In a linear synthesis—often adequate for simple structures—several steps are performed one after another until the molecule is complete. The chemical compounds made in each step are usually deemed synthetic intermediates. For more complex molecules, a different approach may be preferable: convergent synthesis involves the individual preparation of several "pieces" (key intermediates), which are then combined to form the desired product.
Robert Burns Woodward, who received the 1965 Nobel Prize for Chemistry for several total syntheses (e.g., his 1954 synthesis of strychnine), is regarded as the father of modern organic synthesis. Some latter-day examples include Wender's, Holton's, Nicolaou's and Danishefsky's synthesis of Taxol.
Read more about this topic: Organic Synthesis
Famous quotes containing the words total and/or synthesis:
“Parenthood always comes as a shock. Postpartum blues? Postpartum panic is more like it. We set out to have a baby; what we get is a total take-over of our lives.”
—Polly Berrien Berends (20th century)
“The new shopping malls make possible the synthesis of all consumer activities, not least of which are shopping, flirting with objects, idle wandering, and all the permutations of these.”
—Jean Baudrillard (b. 1929)