Nonsense Mutation - Nonsense-mediated MRNA Decay

Nonsense-mediated MRNA Decay

Despite an expected tendency for premature termination codons to yield shortened polypeptide products, in fact the formation of truncated proteins does not occur often in vivo. Many organisms—including humans and lower species, such as yeast—employ a nonsense-mediated mRNA decay pathway, which degrades mRNAs containing nonsense mutations before they are translated into nonfunctional polypeptides.

Read more about this topic:  Nonsense Mutation

Famous quotes containing the word decay:

    It has taken me nearly twenty years of studied self-restraint, aided by the natural decay of my faculties, to make myself dull enough to be accepted as a serious person by the British public; and I am not sure that I am not still regarded as a suspicious character in some quarters.
    George Bernard Shaw (1856–1950)