In genetics, a nonsense mutation is a point mutation in a sequence of DNA that results in a premature stop codon, or a nonsense codon in the transcribed mRNA, and in a truncated, incomplete, and usually nonfunctional protein product. It differs from a missense mutation, which is a point mutation where a single nucleotide is changed to cause substitution of a different amino acid. Some genetic disorders, such as thalassemia and DMD, result from nonsense mutations.
Read more about Nonsense Mutation: Simple Example, Nonsense-mediated MRNA Decay, Pathology Associated With Nonsense Mutations
Famous quotes containing the word nonsense:
“The cot we shared is almost a prison
where I can’t say buttercup, bobolink,
sugarduck, pumpkin, love ribbon, locket,
valentine, summergirl, funnygirl and all
those nonsense things one says in bed.”
—Anne Sexton (1928–1974)