In genetics, a nonsense mutation is a point mutation in a sequence of DNA that results in a premature stop codon, or a nonsense codon in the transcribed mRNA, and in a truncated, incomplete, and usually nonfunctional protein product. It differs from a missense mutation, which is a point mutation where a single nucleotide is changed to cause substitution of a different amino acid. Some genetic disorders, such as thalassemia and DMD, result from nonsense mutations.
Read more about Nonsense Mutation: Simple Example, Nonsense-mediated MRNA Decay, Pathology Associated With Nonsense Mutations
Famous quotes containing the word nonsense:
“You must recollect however that I know nothing of painting & that I detest it, unless it reminds me of something I have seen or think it possible to see.... Depend upon it of all the arts it is the most artificial & unnatural—& that by which the nonsense of mankind is the most imposed upon.”
—George Gordon Noel Byron (1788–1824)