Function
It is related to many functions via its widespread projections. The LC-NA system modulates cortical, subcortical, cerebellar, brainstem and spinal cord circuits. Some of the most important functions influenced by this system are :
Neuroplasticity
Arousal and sleep-wake cycle
Attention and memory
Emotions
Behavioral flexibility, behavioral inhibition and stress (psychological)
Posture and balance.
The locus coeruleus may figure in clinical depression, panic disorder, and anxiety. Some medications including norepinephrine reuptake inhibitors (reboxetine, atomoxetine), serotonin-norepinephrine reuptake inhibitors (venlafaxine, duloxetine), and norepinephrine-dopamine reuptake inhibitors (bupropion) are believed to show efficacy by acting upon neurons in this area.
Read more about this topic: Locus Coeruleus
Famous quotes containing the word function:
“The art of living is to function in society without doing violence to one’s own needs or to the needs of others. The art of mothering is to teach the art of living to children.”
—Elaine Heffner (20th century)
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