Dynamic Kinetic Resolution
Dynamic kinetic resolution (DKR) occurs when the starting material racemate is able to epimerize easily, resulting in an essentially racemic starting material mix at all points during the reaction. Then, the enantiomer with the lower barrier to activation can form in, theoretically, up to 100% yield. This is in contrast to standard kinetic resolution, which necessarily has a maximum yield of 50%. For this reason, dynamic kinetic resolution has extremely practical applications to organic synthesis. The observed dynamics are based on the Curtin-Hammett principle. The barrier to reaction of either enantiomer is necessarily higher than the barrier to epimerization, resulting in a kinetic well containing the racemate. This is equivalent to writing, for kR>kS,
A number of excellent reviews have been published, most recently in 2008, detailing the theory and practical applications of DKR.
Read more about this topic: Kinetic Resolution
Famous quotes containing the words dynamic, kinetic and/or resolution:
“Imagination is always the fabric of social life and the dynamic of history. The influence of real needs and compulsions, of real interests and materials, is indirect because the crowd is never conscious of it.”
—Simone Weil (19091943)
“All my stories are webs of style and none seems at first blush to contain much kinetic matter.... For me style is matter.”
—Vladimir Nabokov (18991977)
“The passions do very often give birth to others of a nature most contrary to their own. Thus avarice sometimes brings forth prodigality, and prodigality avarice; a mans resolution is very often the effect of levity, and his boldness that of cowardice and fear.”
—François, Duc De La Rochefoucauld (16131680)