Organs and Tissues Affected By IGF-1
Since many distinct tissue types express the IGF-1 receptor, IGF-1's effects are diverse. It acts as a neurotrophic factor, inducing the survival of neurons. It causes skeletal muscle hypertrophy, by inducing protein synthesis, and by blocking muscle atrophy. It is protective for cartilage cells, and is associated with activation of osteocytes, and thus may be an anabolic factor for bone. Since at high concentrations it is capable of activating the insulin receptor, it can also complement for the effects of insulin.
Read more about this topic: Insulin-like Growth Factor
Famous quotes containing the words organs and, organs and/or affected:
“How can anyone be interested in war?—that glorious pursuit of annihilation with its ceremonious bellowings and trumpetings over the mangling of human bones and muscles and organs and eyes, its inconceivable agonies which could have been prevented by a few well- chosen, reasonable words. How, why, did this unnecessary business begin? Why does anyone want to read about it—this redundant human madness which men accept as inevitable?”
—Margaret Anderson (1886–1973)
“Man has, as it were, become a kind of prosthetic God. When he puts on all his auxiliary organs, he is truly magnificent; but those organs have not grown on him and they still give him much trouble at times.”
—Sigmund Freud (1856–1939)
“The great war that broke so suddenly upon the world two years ago, and which has swept up within its flame so great a part of the civilized world, has affected us very profoundly.... With its causes and its objects we are not concerned. The obscure fountains from which its stupendous flood has burst we are not interested to search for or explore.”
—Woodrow Wilson (1856–1924)