Halofantrine

Halofantrine is a drug used to treat malaria. Halofantrine's structure contains a substituted phenanthrene, and is related to the antimalarial drugs quinine and lumefantrine. Marketed as Halfan, halofantrine is never used to prevent malaria and its mode of action is unknown. A crystallographic study have shown that halofantrine binds to hematin in vitro, suggesting a possible mechanism of action. Alternatively or in addition, halofantrine has been shown to bind to plasmpesin, a haemoglobin degrading enzyme unique to the malarial parasites.