Growth Factor - Classes of Growth Factors

Classes of Growth Factors

Individual growth factor proteins tend to occur as members of larger families of structurally and evolutionarily related proteins. There are many families, which are listed below:

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  • Adrenomedullin (AM)
  • Angiopoietin (Ang)
  • Autocrine motility factor
  • Bone morphogenetic proteins (BMPs)
  • Brain-derived neurotrophic factor (BDNF)
  • Epidermal growth factor (EGF)
  • Erythropoietin (EPO)
  • Fibroblast growth factor (FGF)
  • Glial cell line-derived neurotrophic factor (GDNF)
  • Granulocyte colony-stimulating factor (G-CSF)
  • Granulocyte macrophage colony-stimulating factor (GM-CSF)
  • Growth differentiation factor-9 (GDF9)
  • Hepatocyte growth factor (HGF)
  • Hepatoma-derived growth factor (HDGF)
  • Insulin-like growth factor (IGF)
  • Migration-stimulating factor
  • Myostatin (GDF-8)
  • Nerve growth factor (NGF) and other neurotrophins
  • Platelet-derived growth factor (PDGF)
  • Thrombopoietin (TPO)
  • Transforming growth factor alpha(TGF-α)
  • Transforming growth factor beta(TGF-β)
  • Tumor_necrosis_factor-alpha(TNF-α)
  • Vascular endothelial growth factor (VEGF)
  • Wnt Signaling Pathway
  • placental growth factor (PlGF)
  • (FBS)
  • IL-1- Cofactor for IL-3 and IL-6. Activates T cells.
  • IL-2- T-cell growth factor. Stimulates IL-1 synthesis. Activates B-cells and NK cells.
  • IL-3- Stimulates production of all non-lymphoid cells.
  • IL-4- Growth factor for activated B cells, resting T cells, and mast cells.
  • IL-5- Induces differentiation of activated B cells and eosinophils.
  • IL-6- Stimulates Ig synthesis. Growth factor for plasma cells.
  • IL-7- Growth factor for pre-B cells.


Stimulates cell cycle from G0 phase to G1 phase

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