In population genetics, genetic load or genetic burden is a measure of the cost of lost alleles due to selection (selectional load) or mutation (mutational load). It is a value in the range, where 0 represents no load. The concept was first formulated in 1937 by JBS Haldane, independently formulated, named and applied to humans in 1950 by H. J. Muller, and elaborated further by Haldane in 1957.
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Famous quotes containing the words genetic and/or load:
“Nature, we are starting to realize, is every bit as important as nurture. Genetic influences, brain chemistry, and neurological development contribute strongly to who we are as children and what we become as adults. For example, tendencies to excessive worrying or timidity, leadership qualities, risk taking, obedience to authority, all appear to have a constitutional aspect.”
—Stanley Turecki (20th century)
“Men so noble,
However faulty, yet should find respect
For what they have been. ‘Tis a cruelty
To load a falling man.”
—William Shakespeare (1564–1616)