Cuauhtémoc
... Cuauhtémoc took power in 1520 as successor of Cuitláhuac and was a cousin of the former emperor Moctezuma II, and his young wife, who would later be known as Isabel Moctezuma, was one of Moctezuma's daughters ... He ascended to the throne when he was 25 years of age, as his city was being besieged by the Spanish and devastated by an epidemic of smallpox brought to the New World by Spanish invaders ...