Active Site
The active site consists of a zinc atom, His-67, Cys-174, Cys-46, Ser-48, His-51, Ile-269, Val-292, Ala-317, and Phe-319. The zinc coordinates the substrate(alcohol). The zinc is coordinated by Cys-46, Cys-174, and His-67. Phe-319, Ala-317, His-51, Ile-269 and Val-292 stabilize NAD+ by forming hydrogen bonds. His-51 and Ile-269 form hydrogen bonds with the alcohols on nicotinamide ribose. Phe-319, Ala-317 and Val-292 form hydrogen bonds with the amide on NAD+.
Read more about this topic: Alcohol Dehydrogenase
Famous quotes containing the words active and/or site:
“So hills and valleys into singing break;
And though poor stones have neither speech nor tongue,
While active winds and streams both run and speak,
Yet stones are deep in admiration.
Thus praise and prayer here beneath the Sun
Make lesser mornings when the great are done.”
—Henry Vaughan (1622–1695)
“The present hour is always wealthiest when it is poorer than the future ones, as that is the pleasantest site which affords the pleasantest prospects.”
—Henry David Thoreau (1817–1862)