The Zincke-Suhl reaction is a special case of a Friedel-Crafts alkylation and was first described by Theodor Zincke and Suhl.
The classic example of this reaction is the conversion of p-cresol to a cyclohexadienone (with the aid of aluminium chloride as a catalyst and tetrachloromethane as a solvent). Melvin Newman, a scientist from the U.S. intensively studied the reaction in the 1950s and reported several improved procedures as well as mechanistic studies.
The reaction product is a starting material in the dienol benzene rearrangement.
Famous quotes containing the word reaction:
“The excessive increase of anything often causes a reaction in the opposite direction.”
—Plato (c. 427–347 B.C.)