History
Porphyrin compounds containing zinc have been known since the 1930s. They became of more than academic interest with the discovery, in 1974, that ZPP was the major non-heme porphyrin formed in red cells as the result of lead poisoning or iron deficiency.
It was already known at this time that non-heme Protoporphyrin IX levels were elevated in these conditions, but prior investigators had used extraction methods that converted ZPP to unbound Protoporphyrin IX.
The early literature is sometimes confusing, and results are hard to compare without detailed examination of the measurement methods and the conversion factors used to report the results. Reports may refer to Free Erythrocyte Protoporphyrin (FEP) or Erythrocyte Protoporphyrin (EP or EPP). ZPP is also abbreviated ZP and ZnPP. Current practice is tending to measure and report the molar ratio of ZPP to Heme (μmole/mole).
Read more about this topic: Zinc Protoporphyrin
Famous quotes containing the word history:
“I believe that history might be, and ought to be, taught in a new fashion so as to make the meaning of it as a process of evolution intelligible to the young.”
—Thomas Henry Huxley (1825–95)
“Racism is an ism to which everyone in the world today is exposed; for or against, we must take sides. And the history of the future will differ according to the decision which we make.”
—Ruth Benedict (1887–1948)
“In front of these sinister facts, the first lesson of history is the good of evil. Good is a good doctor, but Bad is sometimes a better.”
—Ralph Waldo Emerson (1803–1882)