Applications
Zinc finger nucleases have become useful reagents for manipulating the genomes of many plants and animals including arabidopsis, tobacco, soybean, corn, Drosophila melanogaster, C. elegans, sea urchin, silkworm, zebrafish, frogs, mice, rats, rabbits, pigs, cattle, and various types of mammalian cells. Zinc finger nucleases have also been used in a mouse model of haemophilia and an ongoing clinical trial is evaluating Zinc finger nucleases that disrupt the CCR5 gene in CD4+ human T-cells as a potential treatment for HIV/AIDS. ZFNs are also used for the creation of a new generation of genetic disease models called isogenic human disease models.
Read more about this topic: Zinc Finger Nuclease