Zfp36

ZFP36

Identifiers Symbols ZFP36; G0S24; GOS24; NUP475; RNF162A; TIS11; TTP; zfp-36 External IDs OMIM: 190700 MGI: 99180 HomoloGene: 2558 GeneCards: ZFP36 Gene

Gene Ontology
Molecular function	• DNA binding • single-stranded RNA binding • mRNA binding • protein binding • zinc ion binding • AU-rich element binding • protein kinase binding • C-C chemokine binding • metal ion binding • 14-3-3 protein binding
Cellular component	• nucleus • cytoplasm • cytosol • cytoplasmic stress granule
Biological process	• negative regulation of transcription from RNA polymerase II promoter • nuclear-transcribed mRNA poly(A) tail shortening • mRNA catabolic process • response to stress • intracellular protein kinase cascade • gene expression • RNA metabolic process • mRNA metabolic process • regulation of tumor necrosis factor production • negative regulation of myeloid cell differentiation • negative regulation of inflammatory response • RNA destabilization • positive regulation of nuclear-transcribed mRNA poly(A) tail shortening • 3'-UTR-mediated mRNA stabilization
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 7538 22695 Ensembl ENSG00000128016 ENSMUSG00000044786 UniProt P26651 P22893 RefSeq (mRNA) NM_003407 NM_011756 RefSeq (protein) NP_003398 NP_035886 Location (UCSC) Chr 19:
39.9 – 39.9 Mb Chr 7:
28.38 – 28.38 Mb PubMed search

Tristetraprolin (TTP), also known as zinc finger protein 36 homolog (ZFP36), is a protein that in humans, mice and rats is encoded by the ZFP36 gene. It is a member of the TIS11 (TPA-induced sequence) family, along with butyrate response factors 1 and 2.