Yuki Saito may refer to:
- Yuki Saito (actress) (born 1966), singer-songwriter, actress, essayist and poet
- Yuki Saito (pitcher, born 1987), Japanese baseball pitcher for the Hiroshima Toyo Carp
- Yuki Saito (pitcher, born 1988), Japanese baseball pitcher for the Hokkaido Nippon-Ham Fighters