Xylaria Hypoxylon - Bioactive Compounds

Bioactive Compounds

A variety of bioactive compounds have been identified in this fungus. The compounds xylarial A and B both have moderate cytotoxic activity against the human hepatocellular carcinoma cell line Hep G2. The pyrone derivative compounds named xylarone and 8,9-dehydroxylarone also have cytotoxic activity. Several cytochalasins, compounds that bind to actin in muscle tissue, have been found in the fungus. X. hypoxylon also contains a carbohydrate-binding protein, a lectin, with a unique sugar specificity, and which has potent anti-tumor effects in various tumor cell lines.

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