XIST (gene) - X Inactivation Center (XIC)

X Inactivation Center (XIC)

The Xist RNA gene consists of an X Inactivation Center (XIC), which plays a major role in Xist expression and X inactivation. The XIC is located on the q arm of the X chromosome (Xq13). XIC regulates Xist in cis X inactivation, where Tsix, an antisense of Xist, downregulates the expression of Xist. The Xist promoter of XIC is the master regulator of X inactivation. X inactivation plays a key role in dosage compensation.