Gene Location
The human Xist RNA gene is located on the X chromosome of the long (q) arm of chromosome. Xist RNA gene consists of conserved repeats within its structure and is also highly localized in the nucleus. The Xist RNA gene consists of an A region, which contains 8 repeats which are separated by U-rich spacers. The A region appears to contain two long stem-loop structures each that include four repeats. An ortholog of the Xist RNA gene from humans has been also identified in mice. The mouse ortholog is a 15 kb Xist RNA gene that is also localized in the nucleus; however, does not consist of any conserved repeats. The gene also consists of an Xist Inactivation Center (XIC), which plays a major role in X inactivation.
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