X-linked severe combined immunodeficiency (X-SCID) is an immunodeficiency disorder in which the body produces very little T cells and NK cells. In the absence of T cell help, B cells become defective. It is an x-linked recessive trait, stemming from a mutated (abnormal) version of the IL2-RG gene located at xq13.1 on the X-chromosome, which is shared between receptors for IL-2, IL-4, IL-7, and IL-15. (IL2RG).
Read more about X-linked Severe Combined Immunodeficiency: Symptoms, Genetics, Molecular Biology, Diagnosis, Pathophysiology, Treatment, Epidemiology
Famous quotes containing the words severe and/or combined:
“from deep in the dark head
his smile glowing
outward into the
room’s severe twilight,
he lies....”
—Denise Levertov (b. 1923)
“A taste for drink, combined with gout,
Had doubled him up forever.”
—Sir William Schwenck Gilbert (1836–1911)