Wound Healing - Overview of Involved Growth Factors | Overview Involved Growth Factors

Overview of Involved Growth Factors

Following are the main growth factors involved in wound healing:

Growth factor	Abbreviation	Main origins	Effects
Epidermal growth factor	EGF	Activated macrophages Salivary glands Keratinocytes	Keratinocyte and fibroblast mitogen Keratinocyte migration Granulation tissue formation
Transforming growth factor-α	TGF-α	Activated macrophages T-lymphocytes Keratinocytes	Hepatocyte and epithelial cell proliferation Expression of antimicrobial peptides Expression of chemotactic cytokines
Hepatocyte growth factor	HGF	Mesenchymal cells	Epithelial and endothelial cell proliferation Hepatocyte motility
Vascular endothelial growth factor	VEGF	Mesenchymal cells	Vascular permeability Endothelial cell proliferation
Platelet derived growth factor	PDGF	Platelets Macrophages Endothelial cells Smooth muscle cells Keratinocytes	Granulocyte, macrophage, fibroblast and smooth muscle cell chemotaxis Granulocyte, macrophage and fibroblast activation Fibroblast, endothelial cell and smooth muscle cell proliferation Matrix metalloproteinase, fibronectin and hyaluronan production Angiogenesis Wound remodeling Integrin expression regulation
Fibroblast growth factor 1 and 2	FGF-1, -2	Macrophages Mast cells T-lymphocytes Endothelial cells Fibroblasts	Fibroblast chemotaxis Fibroblast and keratinocyte proliferation Keratinocyte migration Angiogenesis Wound contraction Matrix (collagen fibers) deposition
Transforming growth factor-β	TGF-β	Platelets T-lymphocytes Macrophages Endothelial cells Keratinocytes Smooth muscle cells Fibroblasts	Granulocyte, macrophage, lymphocyte, fibroblast and smooth muscle cell chemotaxis TIMP synthesis Angiogenesis Fibroplasia Matrix metalloproteinase production inhibition Keratinocyte proliferation
Keratinocyte growth factor	KGF	Keratinocytes	Keratinocyte migration, proliferation and differentiation
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