Wound Healing - Overview of Involved Growth Factors

Overview of Involved Growth Factors

Following are the main growth factors involved in wound healing:

Growth factor Abbreviation Main origins Effects
Epidermal growth factor EGF
  • Activated macrophages
  • Salivary glands
  • Keratinocytes
  • Keratinocyte and fibroblast mitogen
  • Keratinocyte migration
  • Granulation tissue formation
Transforming growth factor-α TGF-α
  • Activated macrophages
  • T-lymphocytes
  • Keratinocytes
  • Hepatocyte and epithelial cell proliferation
  • Expression of antimicrobial peptides
  • Expression of chemotactic cytokines
Hepatocyte growth factor HGF
  • Mesenchymal cells
  • Epithelial and endothelial cell proliferation
  • Hepatocyte motility
Vascular endothelial growth factor VEGF
  • Mesenchymal cells
  • Vascular permeability
  • Endothelial cell proliferation
Platelet derived growth factor PDGF
  • Platelets
  • Macrophages
  • Endothelial cells
  • Smooth muscle cells
  • Keratinocytes
  • Granulocyte, macrophage, fibroblast and smooth muscle cell chemotaxis
  • Granulocyte, macrophage and fibroblast activation
  • Fibroblast, endothelial cell and smooth muscle cell proliferation
  • Matrix metalloproteinase, fibronectin and hyaluronan production
  • Angiogenesis
  • Wound remodeling
  • Integrin expression regulation
Fibroblast growth factor 1 and 2 FGF-1, -2
  • Macrophages
  • Mast cells
  • T-lymphocytes
  • Endothelial cells
  • Fibroblasts
  • Fibroblast chemotaxis
  • Fibroblast and keratinocyte proliferation
  • Keratinocyte migration
  • Angiogenesis
  • Wound contraction
  • Matrix (collagen fibers) deposition
Transforming growth factor-β TGF-β
  • Platelets
  • T-lymphocytes
  • Macrophages
  • Endothelial cells
  • Keratinocytes
  • Smooth muscle cells
  • Fibroblasts
  • Granulocyte, macrophage, lymphocyte, fibroblast and smooth muscle cell chemotaxis
  • TIMP synthesis
  • Angiogenesis
  • Fibroplasia
  • Matrix metalloproteinase production inhibition
  • Keratinocyte proliferation
Keratinocyte growth factor KGF
  • Keratinocytes
  • Keratinocyte migration, proliferation and differentiation
Unless else specified in boxes, then reference is:

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