Wound Healing - Overview of Involved Growth Factors | Overview Involved Growth Factors

Overview of Involved Growth Factors

Following are the main growth factors involved in wound healing:

Growth factor	Abbreviation	Main origins	Effects
Epidermal growth factor	EGF	Activated macrophages Salivary glands Keratinocytes	Keratinocyte and fibroblast mitogen Keratinocyte migration Granulation tissue formation
Transforming growth factor-α	TGF-α	Activated macrophages T-lymphocytes Keratinocytes	Hepatocyte and epithelial cell proliferation Expression of antimicrobial peptides Expression of chemotactic cytokines
Hepatocyte growth factor	HGF	Mesenchymal cells	Epithelial and endothelial cell proliferation Hepatocyte motility
Vascular endothelial growth factor	VEGF	Mesenchymal cells	Vascular permeability Endothelial cell proliferation
Platelet derived growth factor	PDGF	Platelets Macrophages Endothelial cells Smooth muscle cells Keratinocytes	Granulocyte, macrophage, fibroblast and smooth muscle cell chemotaxis Granulocyte, macrophage and fibroblast activation Fibroblast, endothelial cell and smooth muscle cell proliferation Matrix metalloproteinase, fibronectin and hyaluronan production Angiogenesis Wound remodeling Integrin expression regulation
Fibroblast growth factor 1 and 2	FGF-1, -2	Macrophages Mast cells T-lymphocytes Endothelial cells Fibroblasts	Fibroblast chemotaxis Fibroblast and keratinocyte proliferation Keratinocyte migration Angiogenesis Wound contraction Matrix (collagen fibers) deposition
Transforming growth factor-β	TGF-β	Platelets T-lymphocytes Macrophages Endothelial cells Keratinocytes Smooth muscle cells Fibroblasts	Granulocyte, macrophage, lymphocyte, fibroblast and smooth muscle cell chemotaxis TIMP synthesis Angiogenesis Fibroplasia Matrix metalloproteinase production inhibition Keratinocyte proliferation
Keratinocyte growth factor	KGF	Keratinocytes	Keratinocyte migration, proliferation and differentiation
Unless else specified in boxes, then reference is:

Read more about this topic: Wound Healing

Famous quotes containing the words involved, growth and/or factors:

“Why does philosophy use concepts and why does faith use symbols if both try to express the same ultimate? The answer, of course, is that the relation to the ultimate is not the same in each case. The philosophical relation is in principle a detached description of the basic structure in which the ultimate manifests itself. The relation of faith is in principle an involved expression of concern about the meaning of the ultimate for the faithful.”
—Paul Tillich (1886–1965)

“The English countryside, its growth and its destruction, is a genuine and tragic theme.”
—E.M. (Edward Morgan)

“Girls tend to attribute their failures to factors such as lack of ability, while boys tend to attribute failure to specific factors, including teachers’ attitudes. Moreover, girls avoid situations in which failure is likely, whereas boys approach such situations as a challenge, indicating that failure differentially affects self-esteem.”
—Michael Lewis (late–20th-century)

Related Phrases

Related Words