Wolfram Syndrome - Causes

Causes

It is thought to be caused by both a malfunction of the mitochondria and of myelination, the latter in effect similar to multiple sclerosis. It may have autosomal recessive or dominant or mitochondrial inheritance depending on the genes involved.

Three genetic forms have been described: Wolfram Syndrome 1 (WFS1), Wolfram Syndrome 2 (WFS2) and a possible mitochondrial syndrome.