William Lowndes may refer to:
- William Lowndes (British politician) (1652–1724) British politician and Secretary to the Treasury
- William Lowndes (congressman) (1782–1822) U.S. Congressman from South Carolina
- William Selby Lowndes (c. 1767–1840), British Member of Parliament
- William Thomas Lowndes (c. 1798–1843), English bibliographer, whose principal work was The Bibliographer’s Manual of English Literature
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