William Knox may refer to:
- William Knox (Scottish poet) (1789–1825), Scottish poet and journalist
- William Dunn Knox (1880–1945), Australian artist
- William Shadrach Knox (1843–1914), American congressman from Massachusetts
- William Knox D'Arcy (1849–1917), British entrepreneur
- William Knox (Victorian politician) (1850–1913), Australian politician - House
- Frank Knox (William Franklin Knox, 1874–1944), American Secretary of the Navy
- William Knox (footballer), Scottish professional footballer
- William Knox (Queensland politician) (1927–2001), Australian state politician - Legislative Assembly
- William W. Knox (1911–1981), U.S. federal judge
- William Knox (MP) (1826–1900), MP for Dungannon
- William Knox (British Army officer) (1847–1916), British general
- William Knox (bishop) (1762–1831), Bishop of Killaloe and Kilfenora
- William F. Knox (1885–1975), American football player and coach and lawyer
- Bill Knox (1928–1999), Scottish author
Famous quotes containing the word knox:
“Death is an incident producing clay. Use it, mold it, learn from it.”
—John Gilling, British screenwriter. Dr. Knox (Peter Cushing)