William Draper may refer to:
- William F. Draper (1842–1910), U.S. Representative from Massachusetts
- William Franklin Draper (1912–2003), American painter
- William G. Draper (1920–1964), U.S. Air Force officer and aide to President Dwight D. Eisenhower
- William Henry Draper (1801–1877), lawyer, judge and political figure in Upper Canada and Canada West
- William Henry Draper Jr. (1894–1974), U.S. army officer, banker, and diplomat
- William Henry Draper III, prominent American businessman, son of William Henry Draper Jr.
- William Henry Draper (congressman) (1841–1921), Republican member of the U.S. House of Representatives representing New York
- William Draper (British Army officer) (1721–1787), British lieutenant-general