William Culpepper may refer to:
- William T. Culpepper, III, American politician
- William Colepeper, English politician and poet
- Sir William Culpeper, 1st Baronet of Preston Hall (1588–1651), of the Culpeper baronets
- Sir William Culpeper, 1st Baronet of Wakehurst (died 1651), of the Culpeper baronets
- Sir William Culpeper, 4th Baronet (1668–1740), of the Culpeper baronets