William Bruce may refer to:
- Sir William Bruce, 1st Baronet, of Balcaskie (c. 1630–1710), Scottish architect
- William Bruce, 8th Earl of Kincardine (1710–1740), Scottish nobleman
- William Bruce (cricketer) (1864–1925), Australian cricketer
- William Bruce (Canadian politician) (d. 1838), physician and politician in Upper Canada
- William Bruce (VC) (1890–1914), posthumous recipient of the Victoria Cross
- William Cabell Bruce (1860–1946), author and United States Senator
- Major William Bruce-Gardyne of Clan Gardyne, Laird of Middleton, Angus, Scotland
- William Speirs Bruce (1867–1921), Scottish explorer
- William George Bruce (1856-1949), Milwaukee publisher, historian, and civic leader
Famous quotes containing the word bruce:
“A lot of people say to me, “Why did you kill Christ?” “I dunno ... it was one of those parties, got out of hand, you know.” We killed him because he didn’t want to become a doctor, that’s why we killed him.”
—Lenny Bruce (1925–1966)