William Bassett may refer to:
- William Bassett (by 1531-52 or later), MP for Maldon (UK Parliament constituency)
- William Bassett (died 1553), MP for Derbyshire (UK Parliament constituency)
- William Bassett (died 1586), MP for Glamorgan (UK Parliament constituency)
- William Bassett (died 1601), MP for Staffordshire (UK Parliament constituency)
- William Bassett (Royalist), Royalist MP for Bath, 1640–1642
- William Bassett (1628–1693), MP for Bath, 1669–1693
- William Bassett (actor) (born 1935), American actor
- William Bassett, Jr. (1624–1703), whose daughter Elizabeth Proctor was accused of witchcraft in the 1692 Salem Witch Trials
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