Francis may refer to:
- Francis (given name)
- Francis (surname)
- Francis, Saskatchewan, Canada
- Francis (electoral district)
- Francis Township, Holt County, Nebraska
- Francis, Utah
- Francis the Talking Mule, a mule celebrity, featured in seven movie comedies in the 1950s
- Francis (1950 film), a 1950 comedy film that launched Francis the Talking Mule
- Francis, a 1983 play by Julian Mitchell
- FRANCIS, bibliographic database
- Francis (1793), a colonial schooner in Australian waters 1793–1805