Charles Henry may refer to:
- Charles Henry (librarian) (1859–1926), French librarian and editor
- Brad Henry (Charles Bradford Henry, born 1963), Governor of Oklahoma
- Charles H. Henry (born 1937), physicist
- Charles L. Henry (1849–1927), U.S. Representative from Indiana
- Chuck Henry (born 1946), U.S. TV presenter and newsreader
- Charlie Henry (footballer born 1962), English former footballer for Swindon Town, Torquay United, Northampton Town and Aldershot
- Charlie Henry (footballer born 1986), English footballer
- Sir Charles Solomon Henry, 1st Baronet (1860–1919), British Member of Parliament for Wellington, 1906–1918, and The Wrekin, 1918–1920
- Charles Henry (Canadian politician) (1911–1989), Canadian Member of Parliament
- Charles Henry (basketball), Gonzaga basketball coach for the 1943-44 season
- Charles Henry (Ohio politician), former member of the Ohio Senate
- Charles Henry (American football) (born 1964), former American football player
- Charles J. Henry (born 1950), American librarian