Wali Khan may refer to:
- Wali Khan (khoja), a Turkestani khoja, ruler of Kashgar in 1857.
- Khan Abdul Wali Khan (1917-2006), a Pushtun Pakistani politician.
- 'Abdu'l Wali Khan (1925-2008), an Afghan Prince.
- Asfandyar Wali Khan, son of Khan Abdul Wali Khan, a Pakistani politician.
- Wali Khan Amin Shah, a freedom fighter during the Soviet invasion of Afghanistan and a convicted terrorist.
- Mufti Zar Wali Khan, a Pakistani Muslim cleric.
- Ahmad Wali Khan Karzai, an Afghan politician, brother of president Karzai.
- Wali Khan Babar, Pakistani journalist
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