Inheritance
This condition is usually inherited in an autosomal dominant pattern, which means one copy of the altered gene is sufficient to cause the disorder. In most cases, an affected person has one parent with the condition. A small percentage of cases result from new mutations in the gene; these cases occur in people with no history of the disorder in their family.
Some cases of type II and type IV Waardenburg syndrome appear to have an autosomal recessive pattern of inheritance, which means two copies of the gene must be altered for a person to be affected by the disorder. Most often, the parents of a child with an autosomal recessive disorder are not affected but are carriers of one copy of the altered gene.
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Waardenburg syndrome is usually inherited in an autosomal dominant pattern.
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Types II and IV Waardenburg syndrome may sometimes have an autosomal recessive pattern of inheritance.
Read more about this topic: Waardenburg Syndrome
Famous quotes containing the word inheritance:
“Late in the afternoon we passed a man on the shore fishing with a long birch pole.... The characteristics and pursuits of various ages and races of men are always existing in epitome in every neighborhood. The pleasures of my earliest youth have become the inheritance of other men. This man is still a fisher, and belongs to an era in which I myself have lived.”
—Henry David Thoreau (1817–1862)
“It is very difficult to be wholly joyous or wholly sad on this earth. The comic, when it is human, soon takes upon itself a face of pain; and some of our griefs ... have their source in weaknesses which must be recognized with smiling compassion as the common inheritance of us all.”
—Joseph Conrad (1857–1924)
“I call it our collective inheritance of isolation. We inherit isolation in the bones of our lives. It is passed on to us as sure as the shape of our noses and the length of our legs. When we are young, we are taught to keep to ourselves for reasons we may not yet understand. As we grow up we become the “men who never cry” and the “women who never complain.” We become another generation of people expected not to bother others with our problems.”
—Paula C. Lowe (20th century)