Assembly of VLPs
Previously, the understanding of self-assembly of VLPs was based on viral assembly. This is rational as long as the VLP assembly takes place inside the host cell (in vivo), though the self-assembly event was found in vitro from the very beginning of the study about viral assembly. Study also reals that in vitro assembly of VLPs competes with aggregation, and some believes certain mechanism exist inside the cell to prevent the formation of aggregates while assembly is ongoing.
Read more about this topic: Virus-like Particle
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