Vacuums
In formal terms, a particle is considered to be an eigenstate of the particle number operator a†a, where a is the particle annihilation operator and a† the particle creation operator (sometimes collectively called ladder operators). In many cases, the particle number operator does not commute with the Hamiltonian for the system. This implies the number of particles in an area of space is not a well-defined quantity but, like other quantum observables, is represented by a probability distribution. Since these particles do not have a permanent existence, they are called virtual particles or vacuum fluctuations of vacuum energy. In a certain sense, they can be understood to be a manifestation of the time-energy uncertainty principle in a vacuum.
An important example of the "presence" of virtual particles in a vacuum is the Casimir effect. Here, the explanation of the effect requires that the total energy of all of the virtual particles in a vacuum can be added together. Thus, although the virtual particles themselves are not directly observable in the laboratory, they do leave an observable effect: Their zero-point energy results in forces acting on suitably arranged metal plates or dielectrics.
Read more about this topic: Virtual Particle