Vinculin

Identifiers Symbols VCL; CMD1W; CMH15; MVCL External IDs OMIM: 193065 MGI: 98927 HomoloGene: 7594 GeneCards: VCL Gene

Gene Ontology
Molecular function	• dystroglycan binding • actin binding • structural molecule activity • protein binding • beta-catenin binding • Rho GTPase binding • alpha-catenin binding • cadherin binding
Cellular component	• stress fiber • extracellular region • cytosol • cytoskeleton • actin filament • cell-cell junction • adherens junction • cell-cell adherens junction • fascia adherens • focal adhesion • cell-substrate junction • costamere • protein complex
Biological process	• morphogenesis of an epithelium • platelet degranulation • cellular component movement • muscle contraction • cell adhesion • cell-matrix adhesion • blood coagulation • lamellipodium assembly • platelet activation • negative regulation of cell migration • adherens junction assembly • protein localization to cell surface • apical junction assembly • epithelial cell-cell adhesion
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 7414 22330 Ensembl ENSG00000035403 ENSMUSG00000021823 UniProt P18206 Q64727 RefSeq (mRNA) NM_003373.3 NM_009502.4 RefSeq (protein) NP_003364.1 NP_033528.3 Location (UCSC) Chr 10:
75.76 – 75.88 Mb Chr 14:
20.93 – 21.03 Mb PubMed search See also: Vinculin family

In mammalian cells, vinculin is a membrane-cytoskeletal protein in focal adhesion plaques that is involved in linkage of integrin adhesion molecules to the actin cytoskeleton. Discovered independently by Benny Geiger and Keith Burridge, its sequence is 20%-30% similar to α-catenin, which serves a similar function.