Villa Borghese may refer to:
- The Villa Borghese Pinciana ("Borghese villa on the Pincian Hill"), the villa built by the architect Flaminio Ponzio (and, after his death, finished by his assistant Giovanni Vasanzio), developing sketches by Scipione Borghese, who used it as a villa suburbana, a party villa, at the edge of Rome, and to house his art collection.
- The Galleria Borghese which now occupies the above.
- The Villa Borghese gardens, the gardens in which the above villa is sited
- Any other villas held by the Borghese family
- Villa Borghese (film) a 1953 Italian film directed by Vittorio de Sica
- The Villa is featured in the Eidos videogame Hitman 2.