Clinical Significance
VMAT can be inhibited by reserpine, tetrabenazine and ibogaine.
VMAT is the main target of methamphetamine. By acting as a competitive antagonist, methamphetamine blocks the presynaptic cell's ability to use VMAT to package the above mentioned neurotransmitters into vesicles. The result is increased neurotransmitter release that is not dependent on the phasic activity of the presynaptic cell.
Read more about this topic: Vesicular Monoamine Transporter
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